期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 1, 页码 314-316出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.11.016
关键词
Hydrogen sulfide; Cyanine dye; Serum; Mitochondria; Bioimaging; Near-infrared
资金
- NSF China [21272196, 31221065, 91029304, 81061160512]
- 973 Program [2013CB933901, 2009CB522200]
- NFFTBS [J1210014]
- National Science Foundation of Fujian Province [2011J06004]
- State Key Laboratory of Chemo/biosensing and Chemometrics [2012002]
Cy-Cl, a cationic near-infrared cyanine dye, readily reacts with hydrogen sulfide (H2S) via nucleophilic thiolation to give dose-dependent 'turn-off' fluorescence and colorimetric read-out, allowing selective detection of low levels of H2S in serum and imaging of mitochondrial H2S in living cells. (C) 2013 Elsevier Ltd. All rights reserved.
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