期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 1, 页码 77-82出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.11.080
关键词
Chrysin; Indole; Anti-inflammatory; Anti-nociceptive; Molecular modeling
资金
- CSIR, New Delhi
- DST, New Delhi
- UGC
Six molecules were obtained by the combination of three biologically and medicinally significant moieties- indole, chrysin and pyrazole. Bio-evaluation of these hybrid molecules showed significant inhibition of COX-2 enzymatic activity over that of COX-1 and appreciable anti-nociceptive activity, checked at swiss albino mice. (C) 2013 Elsevier Ltd. All rights reserved.
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