期刊
CCS CHEMISTRY
卷 2, 期 5, 页码 707-728出版社
CHINESE CHEMICAL SOC
DOI: 10.31635/ccschem.020.202000236
关键词
nucleic acid; nanomaterial/DNA hybrid; DNA nanostructures; DNA logic; cell regulation
资金
- NSFC [21788102, 21878086]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX03]
- international cooperation program of Shanghai Science and Technology Committee [17520750100]
- Shanghai Rising-Star Program [19QA1402500]
Since the discovery of the double-helix structure in 1953, nucleic acids have been developed from natural genetic codes into functional building blocks in a wide range of biotechnology and materials sciences. Taking advantage of their design diversity and biocompatibility, functional nucleic acids facilitate the bottom-up fabrication of nanomaterials that are highly potential for molecular medicine to treat different diseases, such as cancers. The present perspective article introduces recent advances in the use of these unique properties of nucleic acid biopolymers for biomedical applications. Specifically, nano-material/nucleic acid hybrid structures for sensing, controlled drug release, programmable intracellular imaging, and apoptosis, as well as logic calculation, are discussed. Furthermore, the detailed operation for both extracellular and intracellular bioactivity regulation with these new design functional nucleic acid nanostructures are fully illustrated.
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