期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 21, 页码 5089-5092出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.08.068
关键词
Sponges; Actinomycetes; Actinokineospora; Actinosporins; Antioxidant
资金
- Australian Research Council [LE0668477, LE0237908]
- DFG [SFB 630 TP A5]
Marine sponge-associated actinomycetes represent an exciting new resource for the identification of new and novel natural products. Previously, we have reported the isolation and structural elucidation of actinosporins A (1) and B (2) from Actinokineospora sp. strain EG49 isolated from the marine sponge Spheciospongia vagabunda. Herein, by employing different fermentation conditions on the same microorganism, we report on the isolation and antioxidant activity of structurally related metabolites, actinosporins C (3) and D (4). The antioxidant potential of actinosporins C and D was demonstrated using the ferric reducing antioxidant power (FRAP) assay. Additionally, at 1.25 mu M, actinosporins C and D showed a significant antioxidant and protective capacity from the genomic damage induced by hydrogen peroxide in the human promyelocytic (HL-60) cell line. (C) 2014 Published by Elsevier Ltd.
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