期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 12, 页码 2717-2719出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.04.046
关键词
Glehnia littoralis; Apiaceae; Dihydropyranocoumarin; Nitric oxide production inhibitor
资金
- Medical Research Center Program (MRC) through the National Research Foundation of Korea [2008-0062275]
- Ministry of Trade, Industry & Energy (MOTIE) through the fostering project of Osong Academy-Industry Convergence (BAIO) [1415126993]
A new dihydropyranocoumarin, (+)-cis-(30S, 40S)-diisobutyrylkhellactone (1), together with five known compounds, 3'-senecioyl-4'-acetylkhellactone (2), 3'-isovaleryl-4'-acetylkhellactone (3), 3',4'-disenecioylkhellactone (4), 3'-isovaleryl-4'-senecioylkhellactone (5), and 3',4'-diisovalerylkhellactone (6), was isolated from Glehnia littoralis. Their chemical structures were elucidated based on the spectroscopic data interpretation, particularly 1D and 2D NMR data including HMQC and HMBC. All the isolated compounds showed the potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values ranging from 7.4 to 44.3 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
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