期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 12, 页码 2602-2612出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.04.029
关键词
Quadruplex DNA, RNA; Small molecules; Cancer
资金
- Cancer Research UK
- Pancreatic Cancer Research Fund UK
- Medical Research Council UK
Repeated guanine tracts in human and other genomes can form higher-order four stranded structures, termed quadruplexes. In the human genome they have particular prevalence in telomeric and promoter regions and also in 5 '-UTRs and introns. These structures, if unresolved and stabilised by small molecules, can form impediments to transcription and translation, and thus can be considered as a form of gene targeting. This Digest surveys the major types of quadruplex-binding small molecules that have been designed and studied to date and directs attention to directions where future development of more drug-like compounds is likely to be most productive. (C) 2014 Elsevier Ltd.
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