期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 1, 页码 168-172出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.11.048
关键词
Erythrophleum fordii; Leguminosae; Cassaine diterpenoid amide; Anti-angiogenesis
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [KRF-2012K2A4A1034671]
- BK21 Plus program
Angiogenesis plays a critical role in embryonic development and various physiological processes. However, excessive angiogenesis is associated with several pathological conditions including cancer. Angiogenesis is closely related to tumor growth, invasion and metastasis, and is considered a prime target for anticancer therapy. In this study, two new mono cassaine diterpenoid amides (1, 5) and four known compounds (2-4, 6) were isolated from the bark of Erythrophleum fordii (Leguminosae). Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. The effects of isolates on endothelial tube formation on Matrigel were investigated. Among them, compound 3 was found to have the most potent inhibitory effect on the capillary-like structure formation of human umbilical vein endothelial cells (HUVECs). Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
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