期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 9, 页码 2579-2584出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.02.109
关键词
Benzimidazole; Benzoxazole; Oxamic acids; PTP1B; Diabetes; pTyr mimetics
资金
- Aurigene Discovery Technologies, Bangalore
A series of benzoxazole compounds containing oxamic acid were synthesized and screened for the PTP1B inhibition. Compound 31d showed best biochemical potency (K-i) of 6.7 mu M. Structure-activity relationship were explained with the help of molecular modeling approach. (C) 2013 Elsevier Ltd. All rights reserved.
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