期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 17, 页码 5006-5010出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.06.037
关键词
Functionalized nanoparticles; Heterotelechelic PEG oligomer; Pegylation; Selective monoreduction; Cancer cells targeting; USPIO NPs
资金
- European Commission FP7 NAMDIATREAM project [EU NMP4-LA-2010-246479]
- INTERREG IV NAOMI project
A straightforward route is proposed for the multi-gram scale synthesis of heterobifunctional poly(ethylene glycol) (PEG) oligomers containing combination of triethyloxysilane extremity for surface modification of metal oxides and amino or azido active end groups for further functionalization. The suitability of these PEG derivatives to be conjugated to nanomaterials was shown by pegylation of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles (NPs), followed by functionalization with small peptide ligands for biomedical applications. (C) 2013 Elsevier Ltd. All rights reserved.
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