期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 20, 页码 5599-5604出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.08.045
关键词
Crataegus pinnatifida, 8-O-4 ' Neolignans; Cytotoxicities
资金
- Program for State Key Laboratory of Bioactive Substance and Function of Natural Medicines [GTZX201208]
- Innovative Research Team of the Ministry of Education
- Program for Liaoning Innovative Research Team in University
- Scientific Research Starting Foundation for Doctors of Liaoning province of PR China [20121106]
- Foundation from the Project of Education Department of Liaoning province of PR China [L2012358]
Nine new 8-O-4' neolignans, named pinnatifidanin B I-IX (1-9), together with 9 known analogs (10-18) were isolated from the seeds of Crataegus pinnatifida. The structures of 1-18 were determined by spectroscopic methods, including 1D, 2D NMR, CD and HRESIMS analysis. Compounds 8-11, 17 and 18 displayed potent cytotoxic activities against human cancer cell lines, and most interestingly, none of the 6 compounds displayed inhibitory activity against human lung cell line (Mrc5). The 6 cytotoxic compounds are considered to be potential as antitumor agents, which could significantly inhibit the cancer cell growth in a dose-dependent manner and are probably safer than positive control drug. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据