期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 10, 页码 2863-2867出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.03.100
关键词
Potency switch; CHK1; MK2; Kinase; Inhibitor
Chemistry has been developed to access both imidazo[1,2-a]pyrazines and imidazo[1,2-c]pyrimidines. Small structural modifications in both series led to a switch of potency between two kinases involved in mediating cell cycle checkpoint control, CHK1 and MK2. (C) 2013 Elsevier Ltd. All rights reserved.
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