期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 5, 页码 1274-1278出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.01.004
关键词
Haloimidazole; Nitroimidazole; Imidazolium salt; Halogenation; Crystal structure; Antibacterial activity
资金
- MESRS (Ministere de l'Enseignement Superieur et de la Recherche Scientifique)
- ANDRU (Agence Nationale pour le Developpement de la Recherche Universitaire) Algeria
Several new highly functionalized imidazolium derivatives were synthesized, via appropriate synthetic routes, using imidazole, 1-methylimidazole and 2-phenyl-1-methylimidazole as key intermediates. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella thipymurium using disk-diffusion and MIC methods. Crystal X-ray structures are reported for six compounds. (c) 2013 Elsevier Ltd. All rights reserved.
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