期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 22, 页码 6188-6191出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.08.092
关键词
KCNQ2; Kv7.2; Neuropathic pain; Diabetic neuropathy; Acrylamide
Acrylamide (S)-6, a potent and efficacious KCNQ2 (Kv7.2) opener, demonstrated significant activity in two models of neuropathic pain and in the formalin test, suggesting that KCNQ2 openers may be useful in the treatment of neuropathic pain including diabetic neuropathy. (c) 2013 Elsevier Ltd. All rights reserved.
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