期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 21, 页码 5941-5944出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.08.073
关键词
alpha-Hydroxyphosphonates; Transition state mimics; Norovirus 3CL protease; Inhibitors
资金
- National Institutes of Health [AI081891]
The design, synthesis, and evaluation of a series of dipeptidyl alpha-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity. (C) 2013 Elsevier Ltd. All rights reserved.
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