期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 21, 页码 5915-5918出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.08.077
关键词
Traditional Chinese medicine; Antimalarial; Picrorhiza scrophulariiflora
资金
- Australian Research Council (ARC) [LE0668477, LE0237908]
An antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1-3) and seven known compounds (4-10). Compound 10 inhibited the growth of the Plasmodium falciparum 3D7 malarial parasite line, with an IC50 value of 8.3 mu M. This compound accounted for similar to 95% of P. falciparum growth inhibitory activity in the crude extract confirming, for this TCM, that a single compound was responsible for the antimalarial activity. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
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