期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 20, 页码 5609-5613出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.08.043
关键词
CK2; CX-4945; Metastasis; Matrix metalloproteinases; Human lung cancer
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology of Korea [2010-0023292]
- National Research Foundation of Korea [2010-0023292] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Casein kinase 2 (CK2) is known to be involved in various cellular processes such as cell cycle, apoptosis and proliferation. It has been reported that the inhibition of CK2 induced by recently developed small molecule CX4945 shows anti-cancer effects including anti-proliferation and anti-angiogenesis in several different cancers including prostate cancer. Here we report that migration and invasion of A549 human lung cancer cells are suppressed by the inhibition of CK2 induced by CX4945. We found that CX4945 sequentially attenuates the proteins in PI3K/Akt and MAPK pathways, two signaling pathways related with cell migration. This sequential control of signal pathways inhibits the expression of membrane type 1-matrix metalloproteinase and this leads to the selective attenuation of one of the gelatinases, MMP-2, which can degrade components of extracellular matrix, and metastasis of A549 human lung cancer cell. (C) 2013 Elsevier Ltd. All rights reserved.
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