期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 18, 页码 5131-5134出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.07.023
关键词
Cycloalkylthiophene-imine; Benzothiazole; Synthesis; Antiviral activity
资金
- Youth Science Foundation of Hubei Academy of Agricultural Sciences [2011NKYJJ19]
- National Natural Science Foundation of China [31000867]
- Hubei Biopesticide Engineering Research Centre
A series of novel cycloalkylthiophene-imine derivatives containing benzothiazole unit were designed, synthesized and evaluated for their anti-viral activities. The bio-evaluation results indicated that some of the target compounds (such as 5g, 5i, 5u) exhibited good to moderate antiviral effect on CVB5, ADV7 and EV71 viruses, however, these compounds did not have inhibition activity against H1N1 virus. Especially, the compounds 4c and 4d also exhibited high antiviral activities, which provide a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration of active pharmacophores. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据