期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 3, 页码 740-743出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.11.085
关键词
C-Glycosides; Mycobacterium tuberculosis; Carbonic anhydrase; Anti-tubercular activity
资金
- EU Grant (Metoxia)
- FONCyT
- UNLP (Argentina)
- CONICET (Argentina)
A small series of C-cinnamoyl glycoside containing the phenol moiety was tested for the inhibition of the three Mycobacterium tuberculosis beta-carbonic anhydrases (CAs, EC 4.2.1.1) with activities in the low micromolar range detected. The compounds were also tested for the inhibition of growth of M. tuberculosis H(37)Rv strain, leading to the identification of (E)-1-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)-4-(3-hydroxyphenyl)but-3-en-2-one (1) as the first carbonic anhydrase inhibitor with anti-tubercular activity. (c) 2012 Elsevier Ltd. All rights reserved.
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