期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 13, 页码 3976-3978出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.04.038
关键词
Aminodihydroquinoline; Cytotoxicity; Anticancer activity
资金
- National Research Foundation of Korea
- Korea government [2011-0030699]
- SRC Research Center for Women's Diseases of Sookmyung Women's University
- National Research Foundation of Korea [2011-0030699] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A series of 2-aminodihydroquinoline analogs were synthesized and their in vitro cytotoxicities against metastatic breast adenocarcinoma cell line MDA-MB-231 were tested. Five out of 16 compounds exhibited promising activity and structure-activity relationship revealed major role of dialkylaminoethyl substituents on dihydroquinoline ring for the activity. Two compounds, 5f and 5h, presented cytotoxicity with IC50 values of about 2 mu M when the compounds were treated to the cells without serum. The cell proliferation was inhibited mildly when the cells cultured with serum. Flow cytometry analyses showed that those compounds arrested the cells at G2/M checkpoint when the cell cycle is active while they induce apoptosis when the cell growth is restricted due to the absence of growth factors. These results suggest the two novel compounds may have anticancer activity through cell cycle arrest and pro apoptosis mechanism. (c) 2013 Elsevier Ltd. All rights reserved.
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