期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 20, 页码 5575-5577出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.08.048
关键词
Antiviral agents; Influenza virus; Viral RNA polymerase; Benzofurazan; H1N1
资金
- FP7 FLUINHIBIT project [201634]
- FP7 FLUCURE project [259972]
The identification of a novel hit compound inhibitor of the protein-protein interaction between the influenza RNA-polymerase PA and PB1 subunits has been accomplished by means of high-throughput screening. A small family of structurally related molecules has been synthesized and biologically evaluated with most of the compounds showing micromolar potency of inhibition against viral replication. (C) 2013 Elsevier Ltd. All rights reserved.
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