期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 4, 页码 1099-1103出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.12.003
关键词
Radiolytic transformation; Rotenone; gamma-Irradiation; Pancreatic lipase; Adipocyte differentiation
资金
- Basic Science Research Program of the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0022783]
- National Research Foundation of Korea [2010-0022783] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Radiolytic transformation of the isoflavonoid rotenone (1) with gamma-irradiation afforded two new degraded products, rotenoisins A (2) and (3). The structures of the two new rotenone derivatives were elucidated on the basis of spectroscopic methods. The new products 2 and 3 exhibited significantly enhanced inhibitory activities against pancreatic lipase and adipocyte differentiation in 3T3-L1 cells when compared to parent rotenone. (C) 2012 Elsevier Ltd. All rights reserved.
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