期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 23, 期 4, 页码 955-958出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.12.057
关键词
Conjugation; Oxime; Oligonucleotides; Ferrocene; Viologen
资金
- Agence Nationale pour la Recherche (ANR ECSTASE Project)
Oxime bond formation has been applied to the preparation of oligonucleotides labeled with electrochemical ferrocene and viologen labels. Aminooxy functionalized ferrocene and viologen derivatives were prepared by a straightforward route and efficiently conjugated with aldehyde containing oligonucleotides either at 3' or 5' end. Both labels were found to not disturb the recognition properties of the oligonucleotide. The versatility of the method was further demonstrated by preparing bi-functionalized conjugates with a disulfide at 3' end and an electrochemical label at 5' end. (C) 2012 Elsevier Ltd. All rights reserved.
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