期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 16, 页码 5232-5238出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.06.061
关键词
Xanthoceras sorbifolia Bunge; Triterpenoid saponins; Bioactivity; Sorbifoliaside
Xanthoceras sorbifolia Bunge is widely used as healthy food material and folk medicine in China. Phytochemical investigation on its seeds oil leavings has led to the isolation and identification of seven new oleanane-type triterpenoid saponins named sorbifoliasides A-F (1-6) and bunkankasaponin F (7), along with five known ones (8-12). The structures of the new compounds were elucidated through spectroscopic analysis and chemical derivatization. Among the isolated compounds, 16-oxo-3, 28-O-bidesmosidic triterpenoid saponins (2, 3, 5) were isolated from this plant for the first time. The cytotoxicity of all compounds against the ten selected human cancer cell lines was assayed. Compounds 7 and 9 showed significant activity against all the ten cancer cell lines (IC50 <10 mu M), while compounds 8, 10 and 11 exhibited moderate activity against most of these cancer cell lines. (c) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据