期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 23, 页码 7146-7150出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.09.068
关键词
Anticancer activity; Vincristine-resistant subline; Doxorubicin-resistant subline; X-ray; ESI MS; Polyether ionophores
资金
- Polish National Science Centre (NCN) [2011/03/D/ST5/05884]
Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore antibiotic, with recently reported antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines. Moreover almost all derivatives show stronger activity against LoVo/DX cell line than that of unmodified salinomycin. (C) 2012 Elsevier Ltd. All rights reserved.
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