期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 3, 页码 1326-1329出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.12.083
关键词
Phenolic bisabolane sesquiterpenoid; Marine-derived fungus; Aspergillus sp.; Sponge; Cytotoxic activity
资金
- National Natural Science Foundation of China [41130858, 40776073]
- Ministry of Education of China [20090132110002, IRT0944]
Three new phenolic bisabolane sesquiterpenoid dimers, disydonols A-C (1-3), and one known compound (S)-(+)-sydonol (4) were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was isolated from the sponge Xestospongia testudinaria collected from the South China Sea. Their structures were elucidated on the basis of comprehensive spectral analysis including 1D and 2D NMR spectra and HR-ESI-MS. These compounds were evaluated for cytotoxic activity against HepG-2 and Caski human tumour cell lines. Among them, compounds 1 and 3 exhibited cytotoxicity against the two cell lines. (C) 2011 Elsevier Ltd. All rights reserved.
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