期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 7, 页码 2629-2634出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.01.017
关键词
HCV; GS-9451; NS3 Protease; Solubilizing group
The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys. (C) 2012 Elsevier Ltd. All rights reserved.
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