期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 13, 页码 4368-4372出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.05.001
关键词
Briarane diterpenoids; Biological activity; Dichotella gemmacea; Gorgonian; Structure elucidation
资金
- Natural Science Foundation of China [41076082, 41176125, 81172979]
Six new briarane diterpenoids, gemmacolides T-Y (1-6), were isolated together with three known analogs, juncenolide J (7), praelolide (8), and junceellolide C (9), from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by detailed spectroscopic analysis and comparison with reported data. The absolute configuration was suggested based on biosynthetic considerations. In an in vitro bioassay, compounds 3 and 6 showed potent growth inhibition towards tumor cell lines of A549 and MG63, being stronger than the positive control of adriamycin. These compounds also exhibited weak antimicrobial activity against the bacterium Escherichia coli and the fungi Microbotryum violaceum and Septoria tritici. (C) 2012 Elsevier Ltd. All rights reserved.
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