期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 15, 页码 4975-4978出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.06.024
关键词
BBOX; Carnitine; THP; Stevens rearrangement; Formaldehyde; Fatty acid oxidation; 2-Oxoglutarate (2OG) oxygenase; Trimethyl L-lysine
资金
- Berrow Foundation
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Engineering and Physical Sciences Research Council (EPSRC)
gamma-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II)-dependent oxygenase that catalyses the final step of L-carnitine biosynthesis in animals. BBOX catalyses the oxidation of 3-(2,2,2-trimethylhydrazinium) propionate (THP), a clinically used BBOX inhibitor, to form multiple products including 3-amino-4-(methyamino)butanoic acid (AMBA), which is proposed to be formed via a Stevens type rearrangement mechanism. We report the synthesis of AMBA and confirm that it is a product of the BBOX catalysed oxidation of THP. AMBA reacts with formaldehyde, which is produced enzymatically by BBOX, to give a cyclic adduct. (c) 2012 Elsevier Ltd. All rights reserved.
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