期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 4, 页码 1818-1821出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.10.023
关键词
Stylissamide X; Marine sponge; Cancer; Migration; Metastasis
资金
- Hoansha Foundation
- Uehara Memorial Foundation
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Grants-in-Aid for Scientific Research [22659002, 23102005, 22241053, 21406002] Funding Source: KAKEN
A new proline-rich cyclic octapeptide named stylissamide X (1) was isolated from an Indonesian marine sponge of Stylissa sp. as an inhibitor of cell migration from the guidance of wound-healing assay. The chemical structure of stylissamide X (1) was determined on the basis of spectroscopic analysis, and stereostructure of the amino acids were deduced by Marfey's method. Compound 1 showed inhibitory activity against migration of HeLa cells in the ranges of 0.1-10 mu M concentration through both wound-healing assay and chemotaxicell chamber assay, while the cell viability was maintained more than 75% up to 10 mu M concentration of 1. (C) 2011 Elsevier Ltd. All rights reserved.
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