期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 2, 页码 924-928出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.12.020
关键词
2,4-Thiazolidinedione; Deep eutectic solvent; Rosiglitazone; Diabetes mellitus
资金
- U.G.C., New Delhi, India
A convenient and scalable four-step novel route has been developed for the synthesis of rosiglitazone (8), an antidiabetic drug. This multistep route requires 4-fluoro benzaldehyde (4), 2,4-thiazolidinedione (6) and 2-chloro pyridine (1) as key reactants and gives overall better yield of rosiglitazone. In addition, some steps have been accelerated, which leads to an overall time saving of 10 h. (C) 2011 Elsevier Ltd. All rights reserved.
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