期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 3, 页码 1317-1321出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.12.088
关键词
RNA polymerase-II; Cyclin-dependent kinase inhibitor; Apoptosis; Anti-cancer therapy
资金
- King Saud University
- Islamic Development Bank (IDB)
We herein report the synthesis, biological activity and structure-activity relationship of derivatives of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and benzo[d]imidazole. A lead compound 6o demonstrates potent anti-proliferative activity and the ability to induce cancer cell apoptosis. (C) 2011 Elsevier Ltd. All rights reserved.
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