Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity

The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC50: 0.18 mu M, K1, cholorquine resistant strain). (c) 2012 Elsevier Ltd. All rights reserved.