期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 8, 页码 2701-2704出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.03.002
关键词
Thioureas; Benzo[5,6]cyclohepta[1,2-b]pyridine; Antitumor; Anti-inflammation
资金
- National Natural Science Foundation of China [30973638]
- Jiangsu Enterprise-Academics-Research Innovation Found [BY2011158]
Thiourea derivatives (6a-e) were developed and screened for antitumor and anti-inflammatory activity. Most of the compounds exhibited growth inhibitory effects comparable to 5-fluorouracil in vitro against mammary (MCF-7 and MDA-MB 231) as well as colon (HT-29) carcinoma cells. They also showed stronger anti-inflammatory activity than ibuprofen in vivo in the xylene-induced ear swelling assay in mice. (C) 2012 Elsevier Ltd. All rights reserved.
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