期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 5, 页码 1908-1911出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.01.058
关键词
Dianthus superbus L; Caryophyllaceae; Cyclic peptides; Osteoblastic proliferative activity
资金
- National Natural Science Foundation of China [30830116, 81073009]
- Jiangsu Higher Education Institutions
Two new cyclic peptides, dianthins G-H (1 and 2), together with the known dianthin E (3), were isolated from the traditional Chinese medicinal plant Dianthus superbus. The sequences of cyclic peptides 1 and 2 were elucidated as cyclo(-Gly(1)-Pro(2)-Leu(3)-Thr(4)-Leu(5)-Phe(6)-) and cyclo (-Gly(1)-Pro(2)-Val(3)-Thr(4)-Ile(5)-Phe(6)-), on the basis of ESI tandem mass fragmentation analysis, extensive 2D NMR methods and X-ray diffraction. The isolated three compounds all increase proliferation of MC3T3-E1 cells in vitro using MTT method. (c) 2012 Elsevier Ltd. All rights reserved.
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