期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 7, 页码 2565-2571出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.01.124
关键词
P2X3; Purinergic receptors; Analgesia; Pyrrolo-pyrimidinones; Nociceptive pain
Purinergic receptor P2X3 has been linked to analgesia in a number of pre-clinical models of pain, and is expressed in the human pain perception pathway. Only few P2X3-selective antagonists have been reported to date. This Letter describes the SAR and in vivo analgesic profile of a novel scaffold of selective P2X3 antagonists. (C) 2012 Elsevier Ltd. All rights reserved.
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