期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 1, 页码 561-563出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.10.077
关键词
Cell penetration; Polyproline helix; Mitochondrial localization
资金
- National Science Foundation [CHE-1012316]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1012316] Funding Source: National Science Foundation
The development of cell penetrating peptides (CPPs) for the cellular delivery of attached cargo is an area of growing interest. Many CPPs, however, are found trapped within endosomes, thereby limiting their use as drug delivery agents with sub-cellular applications. Herein, we detail the properties of a highly efficient class of CPPs, cationic amphiphilic polyproline helices (CAPHs), that are found localized to the mitochondria by direct transport into cells. (C) 2011 Elsevier Ltd. All rights reserved.
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