期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 13, 页码 4462-4466出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.04.029
关键词
Alzheimer's disease; Indanone derivatives; Acetylcholinesterase inhibitors; Metal-chelating agents
资金
- Natural Science Foundation of China [20972198]
A series of novel indanone derivatives was designed, synthesised and evaluated as potential agents for Alzheimer's disease. Among them, compound 6a, with a piperidine group linked to indone by a two-carbon spacer, exhibited the most potent inhibitor activity, with an IC50 of 0.0018 mu M for AChE; the inhibitory activity of this compound was 14-fold more potent than that of donepezil. Furthermore, these compounds also exhibited good metal-chelating ability. (C) 2012 Elsevier Ltd. All rights reserved.
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