期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 22, 期 12, 页码 4111-4116出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.04.063
关键词
Integrin alpha(5)beta(1) antagonist; Zwitterion; RGD integrin; Angiogenesis
Potent antagonists of the integrin alpha(5)beta(1), which are RGD mimetics built from tyrosine are described. This letter describes the optimization of in vitro potency obtained by variation of two parts of the molecule, the basic group and the linker between the basic group and the phenyl central core. (C) 2012 Elsevier Ltd. All rights reserved.
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