期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 22, 页码 6709-6713出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.09.053
关键词
Synthesis; Benzocoumarin; Statins; Antidyslipidemic
资金
- CSIR, New Delhi, India
The synthesis of a series of benzocoumarin keto-enamine schiff bases is reported. The novel compounds were evaluated for their antihyperlipidemic activity in the hyperlipidemic hamster model. The compound 11 at a dose of 10 mg/kg body weight significantly lowered the plasma triglyceride levels (TG) by 70%, total cholesterol (TC) by 47%, accompanied by an increase in HDL-C/TC ratio by 80% in hyperlipidemic hamsters to a greater degree than the reference drugs atorvastatin and lovastatin. (C) 2011 Elsevier Ltd. All rights reserved.
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