期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 18, 页码 5363-5369出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.07.012
关键词
Curcuma kwangsiensis; Diarylheptanoid; Inhibition of nitric oxide production; Macrophages
资金
- National Key Science and Technology Special Project [2009ZX09301-012]
- Program for Liaoning Excellent Talents in University [LR201037]
Eleven diarylheptanoids (1-11) were isolated from rhizomes of Curcuma kwangsiensis, together with seven known compounds. Their structures were elucidated by 1D and 2D NMR, circular dichroism (CD), and accurate mass measurements. Inhibitory effects of the isolated compounds on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated. Compounds 1, 2, and 3 showed strong inhibitory activity on NO production with IC50 values of 3.13, 2.81 and 2.41 mu M, respectively. (C) 2011 Elsevier Ltd. All rights reserved.
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