期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 19, 页码 5842-5848出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.07.107
关键词
Premature termination codons; Organic synthesis; Readthrough compounds; Thiazolidinones
资金
- National Institutes of Health [NS052528]
- A-T Medical Research Foundation
- AT Ease Foundation
- Scott Richards Charitable Trust
A structure-activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity. (C) 2011 Elsevier Ltd. All rights reserved.
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