期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 7, 页码 1974-1977出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.02.031
关键词
Toosendanin; 28-Acyloxy derivatives; Semisynthesis; Insecticidal activity
资金
- State Education Ministry of China [NCET-06-0868]
- National Natural Science Foundation of China [31071737]
- Fok Ying Tong Education Foundation for Young Talents [121032]
- Central Colleges
In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, twelve 28-acyloxy derivatives of toosendanin (2a-l) were semisynthesized and preliminarily evaluated their activity against the pre-third-instar larvae of Mythimna separata Walker in vivo at the concentration of 1 mg/mL. Some compounds exhibited the potent insecticidal activity. Especially compounds 2c and 2j displayed the more promising insecticidal activity than their natural precursor, toosendanin, a commercial insecticide derived from Melia azedarach at 1 mg/mL. In general, it indicated that the butanoyloxy or phenylacryloyloxy moiety at the 28-position of toosendanin was essential for the insecticidal activity. (C) 2011 Elsevier Ltd. All rights reserved.
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