期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 1, 页码 584-587出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.10.032
关键词
Protein kinase C; Kinase inhibitor; Pyrrolopyrazole; Diabetic complications
A novel series of pyrrolopyrazole-based protein kinase C beta II inhibitors has been identified from high-throughput screening. Herein, we report our initial structure-activity relationship studies with a focus on optimizing compound ligand efficiency and physicochemical properties, which has led to potent inhibitors with good cell permeability. (C) 2010 Elsevier Ltd. All rights reserved.
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