Drug Targeting via Platelet Membrane-Coated Nanoparticles

Platelets exhibit distinct surface moieties responsible for modulating their adhesion to various disease-relevant substrates involving vascular damage, immune evasion, and pathogen interactions. Such broad biointerfacing capabilities of platelets have inspired the development of platelet-mimicking drug carriers that preferentially target drug payloads to disease sites for enhanced therapeutic efficacy. Among these carriers, platelet membrane-coated nanoparticles (denoted PNPs) made by cloaking synthetic substrates with the plasma membrane of platelets have emerged recently. Their top-down design combines the functionalities of natural platelet membrane and the engineering flexibility of synthetic nanomaterials, which together create synergy for effective drug delivery and novel therapeutics. Herein, the recent progress of engineering PNPs with different structures for targeted drug delivery is reviewed, focusing on three areas, including targeting injured blood vessels to treat vascular diseases, targeting cancer cells for cancer treatment and detection, and targeting drugresistant bacteria to treat infectious diseases. Overall, current studies establish PNPs as versatile nanotherapeutics for drug targeting with strong potentials to improve the treatment of various diseases.