期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 22, 页码 6884-6887出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.09.021
关键词
Myristica fragrans; Myristicaceae; Phenolic; Anti-inflammatory activity
资金
- National Research Foundation of Korea
- Korean Government (MEST) [KRF-2009-0084675]
Three new phenolics: ((7S)-8'-(benzo[3',4']dioxol-1'-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8'- (4'-hydroxy-3'-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8'S)-7-(4-hydroxy-3-methoxyphenyl)-8'-methylbutan-8-yl)-3'-methoxybenzene-4',5'-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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