期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 22, 页码 6788-6792出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.09.034
关键词
Hepatitis C; Modified purine; Nucleoside analog; Antiviral; Adenosine deaminase
资金
- NIH [2P30-AI-050409, 5R37-AI-041980]
- Department of Veterans Affairs
Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells. Published by Elsevier Ltd.
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