期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 16, 页码 4768-4772出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.06.073
关键词
Natural products; (-)-A26771B; Antibacterial; Macrolactams; Metathesis
Promising synthetic derivatives of macrolactone natural product (-)-A26771B have been designed and synthesized both from semisynthesis and total synthesis. Further optimization led to the first synthesis of macrolactam analogs of (-)-A26771B with improved antibacterial activity and metabolic stability. (C) 2011 Elsevier Ltd. All rights reserved.
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