期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 13, 页码 3939-3942出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.05.022
关键词
CD38; Flavonoids; Anthocyanidins; Inhibition; Docking
资金
- CNRS
- French Ministry of Research
- Agence Nationale de la Recherche [ANR-05-BLAN-0076]
CD38 is a multifunctional enzyme which is ubiquitously distributed in mammalian tissues. It is involved in the conversion of NAD(P)(+) into cyclic ADP-ribose, NAADP(+) and ADP-ribose and the role of these metabolites in multiple Ca(2+) signaling pathways makes CD38 a novel potential pharmacological target. The dire paucity of CD38 inhibitors, however, renders the search for new molecular tools highly desirable. We report that human CD38 is inhibited at low micromolar concentrations by flavonoids such as luteolinidin, kuromanin and luteolin (IC(50) < 10 mu M). Docking studies provide some clues on the mode of interaction of these molecules with the active site of CD38. (C) 2011 Elsevier Ltd. All rights reserved.
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