期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 5, 页码 1512-1514出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.12.122
关键词
Radiolytic transformation; Curcumin; gamma-Lactones; Phenylpropanoids; Pancreatic lipase
资金
- Ministry of Education, Science and Technology [2010-0022783]
- National Research Foundation of Korea [2010-0022783] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The naturally occurring yellow dietary diarylheptanoid curcumin (1) was converted by gamma-ray to two new gamma-lactones, curculactones A (2) and B (3), as well as four known transformates, erythro-1-(3-methoxy-4-hydroxy- phenyl)-propan-1,2-diol (4), threo-1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol (5), vanillic acid (6), and vanillin (7). The structures of the two new gamma-lactone derivatives were elucidated on the basis of spectroscopic methods. The steroisomeric phenylpropanoids 4 and 5 exhibited significantly enhanced inhibitory activity against pancreatic lipase when compared to parent curcumin. (C) 2010 Elsevier Ltd. All rights reserved.
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