Substituted imidazole derivatives as novel cardiovascular agents

A series of novel substituted imidazole derivatives were synthesized and have been screened in vivo for their hypotensive and acute toxicity activities. Out of seventeen compounds eight compounds (2b, 2c, 3b, 3c, 3f, 4a, 4b and 4c) have shown good hypotensive & bradycardiac responses. Compounds 3b, 3c, 3f & 4c have shown better activity than reference drug clonidine. All the compounds have shown ALD50>1000mg/kg with maximum in 2e & 4c (>1200mg/kg). (C) 2010 Elsevier Ltd. All rights reserved.